Nfl Week 6 Point Spreads 2025. The home of our free week 6 nfl picks and predictions. View all nfl odds, point spreads and futures > nfl week 6 odds and betting week 6 of the nfl season kicks off with a thursday night football matchup between the san francisco 49ers.

Expert analysis and top picks for informed betting decisions. Includes opening lines and current spread, moneyline, and totals.